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Safety data sheet

Standardized safety protocols and material specifications for professional use.

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Certificate of Analysis

Purity verified via High-Performance Liquid Chromatography (HPLC) for #myo-adipotide-5mg

Official Product Data Sheet

Adipotide (5mg)

High >98.8% Purity

Vial Contents

5 mg Adipotide (lyophilized powder)

Includes

3 ml bacteriostatic water for reconstitution

Form

Freeze-dried white powder for optimal preservation and stability

Purity

≥98%, third-party verified (COA available)

Sequence

CKGGRAKDC-GG-D(KLAKLAK)₂

Molecular Formula

C₁₅₂H₂₅₂N₄₄O₄₂

Molecular Mass

~2611 g/mol

CAS No.

Investigational (no standard CAS assigned)

Solubility

Reconstitutes with bacteriostatic water to ~1.67 mg/mL (3 ml per vial)

Storage

Lyophilized frozen at −20 °C; reconstituted refrigerated at 2–8 °C for 2–4 weeks

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Scientific Background

Adipotide (also known as FTPP – Fat-Targeted Proapoptotic Peptide) is a synthetic chimeric peptide designed to selectively target and destroy blood vessels that supply white adipose tissue (fat cells).

It consists of a cyclic peptide (CKGGRAKDC) that homes to prohibitin on fat vasculature, linked to a pro-apoptotic sequence (D(KLAKLAK)₂) that induces cell death in targeted endothelial cells, leading to fat tissue starvation and reduction.

Preclinical research in obese monkey and mouse models has shown significant weight loss (up to 11–39% body weight reduction) with preferential loss of visceral fat, improved insulin sensitivity, and no major impact on lean mass.

As an investigational compound, Adipotide is not approved for therapeutic use and is provided strictly for research purposes into targeted fat reduction, vascular biology, and metabolic regulation.

Intended Research Use

Targeted fat reduction via adipose vasculature disruption
Visceral fat loss research in obesity models
Insulin sensitivity and metabolic regulation studies
Vascular biology and prohibitin-targeting research
Weight management support research

menu_bookScientific Publications

article

Proc Natl Acad Sci U S A (2004)

Cytokine-induced killer cells kill tumor cells with a novel chimeric receptor targeting the tumor vasculature

open_in_newhttps://pubmed.ncbi.nlm.nih.gov/15273290/

article

J Clin Invest (2006)

Ligand-directed surface profiling of human adipose tissue vasculature

open_in_newhttps://pubmed.ncbi.nlm.nih.gov/16710477/

article

Sci Transl Med (2011)

A peptidomimetic targeting white fat causes weight loss and improved insulin sensitivity in obese monkeys

open_in_newhttps://pubmed.ncbi.nlm.nih.gov/22072637/

warning

FOR RESEARCH USE ONLY. This product is intended for laboratory research purposes only and is not for human consumption, medical, or diagnostic use.

Possible stacks with other peptides

Synergistic combinations for enhanced research outcomes

Adipotide can be combined with complementary peptides to enhance fat loss and metabolic outcomes in research protocols focused on targeted adipose reduction.