HGH Fragment (AOD-9604) (5mg)

AOD-9604 (also known as HGH Fragment 177–191) is a synthetic 16-amino-acid peptide representing the C-terminal fragment of human growth hormone. It was developed in the late 1990s as a targeted lipolytic agent designed to replicate the fat-burning activity of full hGH without the negative metabolic consequences associated with IGF-1 elevation, insulin resistance, or uncontrolled cellular proliferation.

AOD-9604 stimulates lipolysis and inhibits lipogenesis through direct interaction with the beta-3 adrenergic receptor pathway in adipose tissue — activating fat breakdown mechanisms in obese animal models by more than 50% compared to controls. Critically, it does not raise IGF-1, does not cause glucose dysregulation, and produced no antibody formation in clinical trials.

Beyond its primary metabolic research applications, AOD-9604 has also been studied in joint health models, where intra-articular administration improved cartilage regeneration markers in osteoarthritis models — an effect further enhanced by combination with hyaluronic acid. Its dual metabolic and tissue-repair research utility makes it a versatile compound for investigative protocols.