Safety data sheet
Standardized safety protocols and material specifications for professional use.
Certificate of Analysis
Purity verified via High-Performance Liquid Chromatography (HPLC) for #myo-aicar-50mg
AICAR (50mg)
Ultra High >99.7% Purity
Authorized Resellers
Available through our trusted partners
123peptide.com
Netherlands · Europe
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Depeptidenwinkel.com
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Scientific Background
AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) is a research compound that activates AMP-activated protein kinase (AMPK), earning the nickname "exercise pill" after studies showed sedentary animals given AICAR experienced dramatic endurance improvements.
AICAR functions as an AMPK agonist, mimicking an energy-depleted cellular state. After administration, AICAR enters skeletal muscle and other cells where it is metabolized to ZMP (AICAR monophosphate), an analog of AMP that directly activates AMPK.
AMPK serves as the master regulator of cellular energy homeostasis, and its activation stimulates glucose uptake and fatty-acid oxidation in muscle while promoting mitochondrial biogenesis to boost cellular energy output. This metabolic shift activates pathways that improve energy metabolism and endurance capacity.
AICAR is prohibited in competitive sports (WADA classifies it as a metabolic modulator) and is not approved for therapeutic use in humans. Provided strictly for research purposes.
Intended Research Use
- AMPK activation and exercise-mimetic metabolic research
- Mitochondrial biogenesis and endurance enhancement studies
- Fatty acid oxidation and glucose metabolism research
- Insulin sensitivity and metabolic syndrome investigation
- Diabetic neuropathy protection research
menu_bookScientific Publications
Am J Physiol Regul Integr Comp Physiol (2010)
AICAR treatment normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/20844264/
Int J Mol Sci (2024)
Administration of AICAR, an AMPK Activator, Prevents and Reverses Diabetic Polyneuropathy by Regulating Mitophagy
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/39795939/
Biochem Biophys Res Commun (2006)
AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/16364253/
Biochem J (2005)
5-Aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/15357422/
FOR RESEARCH USE ONLY. This product is intended for laboratory research purposes only and is not for human consumption, medical, or diagnostic use.
Possible stacks with other peptides
Synergistic combinations for enhanced research outcomes
AICAR can be combined with other metabolic and mitochondrial peptides for synergistic AMPK activation and enhanced energy metabolism research.
