Safety data sheet
Standardized safety protocols and material specifications for professional use.
Certificate of Analysis
Purity verified via High-Performance Liquid Chromatography (HPLC) for #myo-melanotan-ii-10mg
Melanotan II (10mg)
Ultra High >99.9% Purity
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Scientific Background
Melanotan II (MT-II) is a synthetic cyclic analog of alpha-melanocyte-stimulating hormone (α-MSH), designed as a non-selective melanocortin receptor agonist with potent activity at MC1R, MC3R, MC4R, and MC5R. Originally developed in the 1980s at the University of Arizona, it was the precursor compound from which the more targeted PT-141 (bremelanotide) was derived.
MC1R activation drives melanogenesis — the production of eumelanin (brown/black skin pigment) in melanocytes. MC4R activation in the hypothalamus modulates appetite, sexual arousal, and autonomic functions. MC3R plays roles in energy homeostasis and inflammatory regulation. MC5R is involved in exocrine gland function. This broad receptor profile produces MT-II's distinctive combination of effects: skin tanning, sexual arousal, appetite suppression, and spontaneous erections in male subjects.
As an investigational compound, Melanotan II provides a valuable model for melanocortin receptor pharmacology research, studying the interplay between pigmentation, appetite, sexual function, and metabolic regulation. It is not approved for therapeutic use and is provided strictly for research purposes.
Intended Research Use
- Broad-spectrum melanocortin receptor (MC1R/MC3R/MC4R/MC5R) pharmacology research
- Melanogenesis and skin pigmentation studies via MC1R activation
- MC4R-mediated sexual arousal and libido pathway research
- Appetite suppression and energy homeostasis research via MC4R/MC3R signaling
- Spontaneous penile erection models in male rodent studies
- Comparative receptor selectivity studies versus Melanotan I and PT-141
- Melanocortin system and metabolic/reproductive axis interaction research
menu_bookScientific Publications
Peptides (1996)
Melanotan II, a potent melanocortin receptor agonist, stimulates penile erection via a peripheral mechanism
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/8984386/
Life Sci (1997)
Melanocortin receptors, melanotropic peptides and penile erection: a review
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/9042376/
J Sex Med (2007)
Bremelanotide: an overview of preclinical CNS effects on female sexual function
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/17316383/
Pharmacol Biochem Behav (2003)
Melanotan II inhibits food intake via the MC4 receptor in rats
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/12782271/
Peptides (2005)
Melanocortin receptors, melanotropic peptides and penile erection
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/15797608/
J Clin Endocrinol Metab (2000)
Melanotan II as a treatment for male sexual dysfunction: phase I/II study
open_in_newhttps://pubmed.ncbi.nlm.nih.gov/10720057/
Research Note: Melanotan II's broad melanocortin receptor activation profile produces multiple simultaneous effects: MC1R drives melanogenesis (tanning), MC4R mediates sexual arousal and appetite suppression, and MC3R modulates energy balance. This multi-receptor activity makes MT-II valuable for studying melanocortin system interactions but also produces more side effects than receptor-selective compounds like Melanotan I (MC1R-selective) or PT-141 (MC4R-biased). Understanding this receptor profile is essential for proper research design.
FOR RESEARCH USE ONLY. This product is intended for laboratory research purposes only and is not for human consumption, medical, or diagnostic use.
Possible stacks with other peptides
Synergistic combinations for enhanced research outcomes
Melanotan II's multi-receptor activity makes it a versatile research compound for studying melanocortin system interactions. Research combinations typically focus on complementary skin, sexual health, or metabolic pathways.
Melanotan I (10mg vial)
arrow_forwardmyo-melanotan-i-10mg
MC1R-selective alternative for comparative receptor selectivity research — pure tanning without MC4R effects.
PT-141 (Bremelanotide) (10mg vial)
arrow_forwardmyo-pt-141-bremelanotide-10mg
MC4R-biased derivative of MT-II for focused sexual function research with regulatory precedent.
GHK-Cu (50mg vial)
arrow_forwardmyo-ghk-cu-50mg
Skin collagen synthesis and repair complement to MT-II melanogenesis for comprehensive skin health research.
Melanotan II Injection Pen (10mg vial)
arrow_forwardmyo-melanotan-ii-injection-pen-10mg
Pre-loaded injection pen format for precise, convenient dosing in extended Melanotan II research protocols.
Cycling Note: MT-II pigmentation effects develop over 2–4 weeks with daily dosing, then maintenance can be reduced to every 2–3 days. Research cycles of 4–8 weeks loading followed by reduced maintenance dosing are typical.
