HMG (75IU)

Human Menopausal Gonadotropin (HMG), also known as Menotropins, is a purified gonadotropin preparation derived from the urine of post-menopausal women. It contains both FSH (Follicle-Stimulating Hormone) and LH (Luteinising Hormone) activity in an approximately 1:1 ratio, providing comprehensive gonadotropin axis coverage that neither HCG nor gonadorelin alone can replicate.

In male reproductive research, FSH is the critical driver of spermatogenesis — it acts on Sertoli cells within the seminiferous tubules to support sperm maturation, while LH (or HCG as its surrogate) drives testosterone production in Leydig cells. In hypogonadotropic hypogonadism models, where both FSH and LH are deficient, HMG provides the complete gonadotropin signal required to stimulate both Sertoli and Leydig cell function simultaneously.

Research consistently demonstrates that HMG combined with HCG produces superior spermatogenesis induction outcomes compared to HCG alone, with improvements in sperm count, motility, and morphology. HMG is therefore a cornerstone compound in male infertility research where complete FSH/LH coverage is required.