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Safety data sheet

Standardized safety protocols and material specifications for professional use.

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Certificate of Analysis

Purity verified via High-Performance Liquid Chromatography (HPLC) for #myo-gdf-8-myostatin-1mg

Official Product Data Sheet

GDF-8 (Myostatin) (1mg)

Standard >95% Purity

Vial Contents

1 mg GDF-8 (lyophilized powder)

Includes

3 ml bacteriostatic water for reconstitution

Form

Lyophilized white powder

Purity

≥95%, high-purity, third-party tested

Sequence

Recombinant human myostatin (GDF-8)

Molecular Formula

C₂₂₁H₃₄₂N₇₂O₆₇S

Molecular Mass

~25 kDa (dimer)

CAS No.

Not assigned (protein)

Solubility

Reconstitute with bacteriostatic water (3 ml) for ~0.33 mg/mL

Storage

Lyophilized at −20°C; reconstituted refrigerated at 2–8°C for 1–2 weeks

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What is GDF-8?

GDF-8, also known as myostatin, is a recombinant human protein that acts as a natural regulator of muscle growth by limiting cell proliferation and differentiation. It belongs to the TGF-β family and is studied for its role in muscle development control and potential in growth disorders.

GDF-8 is a dimeric glycoprotein produced from the MSTN gene, functioning as a negative regulator in the TGF-β superfamily to inhibit muscle cell growth and differentiation. Preclinical studies show it binds to activin type II receptors to activate Smad signaling, suppressing myoblast proliferation and satellite cell activation. Research highlights its involvement in muscle wasting conditions, with mutations leading to increased muscle mass in animals.

For lab use, reconstitute the 1 mg vial with 3.0 mL bacteriostatic water to reach ~0.33 mg/mL concentration, supporting accurate U-100 syringe readings (1 unit = 0.01 mL ≈ 3.3 mcg). Typical investigative ranges span 10–50 mcg daily for 10–20 days in models.

Intended Research Use

Binds activin receptors to inhibit muscle cell growth via Smad pathways
Regulates myoblast differentiation and satellite cell activity
Involved in muscle homeostasis and wasting mechanisms
Mutations show increased muscle mass in genetic studies
Cachexia and sarcopenia mechanism research

menu_bookScientific Publications

article

Nature (1997)

Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member

open_in_newhttps://pubmed.ncbi.nlm.nih.gov/9139826/

article

N Engl J Med (2004)

Myostatin mutation associated with gross muscle hypertrophy in a child

open_in_newhttps://pubmed.ncbi.nlm.nih.gov/15215484/

article

Proc Natl Acad Sci USA (2001)

Regulation of myostatin activity and muscle growth

open_in_newhttps://pubmed.ncbi.nlm.nih.gov/11459935/

article

PLoS Genet (2007)

A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs

open_in_newhttps://pubmed.ncbi.nlm.nih.gov/17530926/

warning

FOR RESEARCH USE ONLY. This product is intended for laboratory research purposes only and is not for human consumption, medical, or diagnostic use.

Possible stacks with other peptides

Synergistic combinations for enhanced research outcomes

GDF-8/Myostatin can be studied alongside inhibitors and anabolic peptides for comprehensive myostatin pathway and muscle regulation research.

ACE-031 1mg (1mg vial)

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myo-ace-031-1mg

Myostatin inhibitor via ACVR2B decoy receptor — studied alongside GDF-8 for complementary insights into myostatin regulation and muscle hypertrophy research.